Meridia should not be used with any drugs which work on the Central nervous system especially this drug should never be combined with serotonergic agents. It is also advised that the user is cautious about taking these drugs with another drug such as monoamine oxidase inhibitors. These drugs are also known as MAOI. These are like selegiline or phenelzine. Meridia should not be taken with serotonergic agents such as paroxetine, fluoxetine, sertraline, fluvoxamine, venlafaxine and more. The reason is that the users who have combined these drugs have suffered serious ailments and some of the reactions have even been fatal. The reason is that sibutramine stops the reuptake of serotonin. Infact it is suggested that Meridia should not be consumed within a 2 week period of discontinuation of any MAOI.
Other combinations to be avoided
There is serotonin syndrome symptoms observed even when some agents are consumed like lmitrex which is given for migraine therapy or even dihydroergotamine or even opioids such as dextromethorphan, pentazocine, meperidine, fentanyl, tryptophan or lithium with Meridia. When the symptoms are seen, then immediate medical attention is required. The symptoms which are observed are hypomania, excitement, restlessness, confusion, loss of consciousness, anxiety, disorientation, motor weakness, agitation, myoclonus, hermiballismus, tremors, hyperreflexia, dysarthria, ataxia, hyperthermia, incoordination, papillary dilation, shivering, diaphoresis, tachycardia and emesis.
Drugs for heart rate and blood pressure
When Meridia is given then the blood pressure and heart rate may be raised if taken in combination with decongestants, cold, allergy medication, cough medication, ephedrine, pseudoephedrine and more.
When Meridia is taken it is best to avoid excessive consumption of alcohol.
When Meridia is given there is contraindication when the patients are on MAOIs. There is also contraindication if the patients have hypersensitivity to any of the ingredients whether active or inactive which are contained in Meridia or they have hypersensitivity to sibutramine. There is contraindication even with regards patients who are having eating disorders such as bulimia nervosa or anorexia nervosa. There is also contraindication if the patients are taking other drugs which act centrally to ensure there is weight loss.
Common medications that interact
Major drug interactions with Meridia are seen with Adderall, Cymbalta, Phentermine, Prozac, Tramadol and similar drugs. Moderate interactions are seen with drugs such as aspirin, spironolactone, hydrochlorothiazide, lyrica, metformin, and Xanax.
In addition to it, Meridia has interactions with those suffering from cardiovascular diseases, glaucoma, renal or liver diseases. It has moderate interaction for those suffering from substance abuse, diabetes or seizures.
As Meridia is known to react with a total of 222 drugs in a very major way, 713 moderate drug interactions and 41 minor drug interactions as well as with 7 disease interactions, it is important to first check with the medical practitioner before starting this medication as the repercussions could be extremely serious and could even result in fatality. The doctor or medical practitioner should be informed of the entire history and all the medications being taken as well as all the diseases that one has, so he or she can make an informed decision.